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Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification
Human retinoblastoma is a pediatric cancer initiated by RB gene mutations in the developing retina. We have examined the origins and progression of retinoblastoma in mouse models of the disease. Retina-specific inactivation of Rb on a p130−/− genetic background led to bilateral retinoblastoma with r...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1794380/ https://ncbi.nlm.nih.gov/pubmed/17235288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601515 |
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