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Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification

Human retinoblastoma is a pediatric cancer initiated by RB gene mutations in the developing retina. We have examined the origins and progression of retinoblastoma in mouse models of the disease. Retina-specific inactivation of Rb on a p130−/− genetic background led to bilateral retinoblastoma with r...

詳細記述

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書誌詳細
主要な著者: MacPherson, David, Conkrite, Karina, Tam, Mandy, Mukai, Shizuo, Mu, David, Jacks, Tyler
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794380/
https://ncbi.nlm.nih.gov/pubmed/17235288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601515
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