Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacterium smegmatis.

D-Cycloserine is an effective second-line drug against Mycobacterium avium and Mycobacterium tuberculosis. To analyze the genetic determinants of D-cycloserine resistance in mycobacteria, a library of a resistant Mycobacterium smegmatis mutant was constructed. A resistant clone harboring a recombina...

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Pubblicato in:	J Bacteriol
Autori principali:	Cáceres, N E, Harris, N B, Wellehan, J F, Feng, Z, Kapur, V, Barletta, R G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9260945/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.16.5046-5055.1997
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