Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA

The mitomycin C-resistance gene, mcrA, of Streptomyces lavendulae produces MCRA, a protein that protects this microorganism from its own antibiotic, the antitumor drug mitomycin C. Expression of the bacterial mcrA gene in mammalian Chinese hamster ovary cells causes profound resistance to mitomycin...

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Hlavní autoři: Belcourt, Michael F., Penketh, Philip G., Hodnick, William F., Johnson, David A., Sherman, David H., Rockwell, Sara, Sartorelli, Alan C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC17916/
https://ncbi.nlm.nih.gov/pubmed/10468636
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