Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA

The mitomycin C-resistance gene, mcrA, of Streptomyces lavendulae produces MCRA, a protein that protects this microorganism from its own antibiotic, the antitumor drug mitomycin C. Expression of the bacterial mcrA gene in mammalian Chinese hamster ovary cells causes profound resistance to mitomycin...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Belcourt, Michael F., Penketh, Philip G., Hodnick, William F., Johnson, David A., Sherman, David H., Rockwell, Sara, Sartorelli, Alan C.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1999
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17916/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468636/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10489
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