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Bioassay-Guided Evolution of Glycosylated Macrolide Antibiotics in Escherichia coli
Macrolide antibiotics such as erythromycin are clinically important polyketide natural products. We have engineered a recombinant strain of Escherichia coli that produces small but measurable quantities of the bioactive macrolide 6-deoxyerythromycin D. Bioassay-guided evolution of this strain led to...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2007
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1790958/ https://ncbi.nlm.nih.gov/pubmed/17298179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050045 |
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