Structural basis for transcription inhibition by tagetitoxin

Tagetitoxin (Tgt) inhibits plastid-encoded, bacterial and some eukaryotic RNA polymerases (RNAPs) by an unknown mechanism. A 2.4Å-resolution structure of the Thermus thermophilus RNAP/Tgt complex revealed that Tgt-binding site within the RNAP secondary channel overlaps with that of the stringent con...

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Bibliographic Details
Main Authors: Vassylyev, Dmitry G., Svetlov, Vladimir, Vassylyeva, Marina N., Perederina, Anna, Igarashi, Noriyuki, Matsugaki, Naohiro, Wakatsuki, Soichi, Artsimovitch, Irina
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1790907/
https://ncbi.nlm.nih.gov/pubmed/16273103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1015
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