Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape

BACKGROUND: Antigen-specific CTL responses are thought to play a central role in containment of HIV-1 infection, but no consistent correlation has been found between the magnitude and/or breadth of response and viral load changes during disease progression. METHODS AND FINDINGS: We undertook a detai...

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Главные авторы: Karlsson, Annika C., Iversen, Astrid K.N., Chapman, Joan M., de Oliveira, Tulio, Spotts, Gerald, McMichael, Andrew J., Davenport, Miles P., Hecht, Frederick M., Nixon, Douglas F.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2007
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1790860/
https://ncbi.nlm.nih.gov/pubmed/17311088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000225
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