Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid.

An IMP dehydrogenase gene was isolated from Candida albicans on a approximately 2.9-kb XbaI genomic DNA fragment. The putative Candida IMP dehydrogenase gene (IMH3) encodes a protein of 521 amino acids with extensive sequence similarity to the IMP dehydrogenases of Saccharomyces cerevisiae and vario...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Köhler, G A, White, T C, Agabian, N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC178971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9079920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.179.7.2331-2338.1997
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