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Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry

We have developed methods for studying the interactions between small molecules and RNA and have applied them to characterize the binding of three classes of aminoglycoside antibiotics to ribosomal RNA subdomains. High-resolution MS was used to quantitatively identify the noncovalent binding interac...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Griffey, Richard H., Hofstadler, Steven A., Sannes-Lowery, Kristin A., Ecker, David J., Crooke, Stanley T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17854/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468574/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10129
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