Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry

We have developed methods for studying the interactions between small molecules and RNA and have applied them to characterize the binding of three classes of aminoglycoside antibiotics to ribosomal RNA subdomains. High-resolution MS was used to quantitatively identify the noncovalent binding interac...

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Bibliografiske detaljer
Main Authors: Griffey, Richard H., Hofstadler, Steven A., Sannes-Lowery, Kristin A., Ecker, David J., Crooke, Stanley T.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17854/
https://ncbi.nlm.nih.gov/pubmed/10468574
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