Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry

We have developed methods for studying the interactions between small molecules and RNA and have applied them to characterize the binding of three classes of aminoglycoside antibiotics to ribosomal RNA subdomains. High-resolution MS was used to quantitatively identify the noncovalent binding interac...

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Detaylı Bibliyografya
Asıl Yazarlar: Griffey, Richard H., Hofstadler, Steven A., Sannes-Lowery, Kristin A., Ecker, David J., Crooke, Stanley T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 1999
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC17854/
https://ncbi.nlm.nih.gov/pubmed/10468574
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