Vertical and horizontal dissemination of an IncC plasmid harbouring rmtB 16S rRNA methylase gene, conferring resistance to plazomicin, among invasive ST258 and ST16 KPC-producing Klebsiella pneumoniae

Objectives: Carbapenem resistance in Klebsiella pneumoniae is a major clinical challenge. Aminoglycosides remain an important asset in the current therapeutic arsenal to treat these infections. We examined aminoglycoside resistance phenotypes and genomics in a collection of 100 invasive KPC-producin...

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Principais autores:	Mélanie Roch, Roberto Sierra, Kirsty Sands, Willames M.B.S. Martins, Jacques Schrenzel, Timothy R. Walsh, Ana C. Gales, Diego O. Andrey
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2021-03-01
Serija:	Journal of Global Antimicrobial Resistance
Teme:	KPC-producing Klebsiella pneumoniae 16S rRNA methyltransferase rmtB Apramycin Plazomicin Aminoglycosides
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2213716520303209
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