Changing landscape of 16 S-RMTase-mediated aminoglycoside resistance in clinical Klebsiella pneumoniae isolates from Chile between 1997 and 2023

Abstract The emergence of 16S rRNA methyltransferase (16S-RMTases) poses a major therapeutic challenge, as they confer high-level resistance to all clinically relevant aminoglycosides. In Chile, data on these enzymes remain scarce. This study investigated the epidemiological distribution and genetic...

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Autores principales:	Maximiliano Matus-Köhler, Rocío Rivas-Carrasco, Luis Amsteins-Romero, Mario Quezada-Aguiluz, Francisco Astorga-Ríos, Felipe Maurelia, Celia A. Lima, Néstor Herrera-Chávez, Andrés Opazo-Capurro, Gerardo González-Rocha, Felipe Morales-León, Helia Bello-Toledo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-05-01
Colección:	Scientific Reports
Materias:	Aminoglycosides 16S rRNA methyltransferase Antibiotic resistance Klebsiella pneumoniae Epidemiology
Acceso en línea:	https://doi.org/10.1038/s41598-026-51336-x
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