Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB retention and pericyte recruitment in vivo, suggesting a potential role for heparan sulfate (HS) in PDGF...

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Hlavní autoři: Abramsson, Alexandra, Kurup, Sindhulakshmi, Busse, Marta, Yamada, Shuhei, Lindblom, Per, Schallmeiner, Edith, Stenzel, Denise, Sauvaget, Dominique, Ledin, Johan, Ringvall, Maria, Landegren, Ulf, Kjellén, Lena, Bondjers, Göran, Li, Jin-ping, Lindahl, Ulf, Spillmann, Dorothe, Betsholtz, Christer, Gerhardt, Holger
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2007
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785125/
https://ncbi.nlm.nih.gov/pubmed/17289920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.398207
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