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Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?

Recent molecular analyses of leukemic blasts from pretreatment marrow or blood of patients with acute myeloid leukemia (AML) and a normal karyotype, the largest cytogenetic subset (ie, 40%-49%) of AML, have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and...

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Bibliografiske detaljer
Main Authors: Mrózek, Krzysztof, Marcucci, Guido, Paschka, Peter, Whitman, Susan P., Bloomfield, Clara D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785102/
https://ncbi.nlm.nih.gov/pubmed/16960150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-001149
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