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Acetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and E. coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex
Two analogues of pyruvate, acetylphosphinate and acetylmethylphosphinate were tested as inhibitors of the E1 (pyruvate dehydrogenase) component of the human and Escherichia coli pyruvate dehydrogenase complexes. This is the first instance of such studies on the human enzyme. The acetylphosphinate is...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783836/ https://ncbi.nlm.nih.gov/pubmed/17070897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2006.09.001 |
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