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Conversions of Formaldehyde-modified 2′-Deoxyadenosine 5′-Monophosphate in Conditions Modeling Formalin-fixed Tissue Dehydration

Formalin-fixed, paraffin-embedded specimens typically provide molecular biologists with low yields of extractable nucleic acids that exhibit extensive strand cleavage and covalent modification of nucleic acid bases. This study supports the idea that these deleterious effects are promoted by the firs...

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Detalhes bibliográficos
Main Authors: Rait, Vladimir K., Zhang, Qingrong, Fabris, Daniele, Mason, Jeffrey T., O’Leary, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783762/
https://ncbi.nlm.nih.gov/pubmed/16116034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/jhc.5A6725.2005
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