A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFβ regulation

The Runt domain is the DNA binding domain of the core binding factor (CBF) Runx subunits. The CBFs are transcription factors that play critical roles in hematopoiesis, bone, and neuron development in mammals. A common non-DNA binding CBFβ subunit heterodimerizes with the Runt domain of the Runx prot...

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Main Authors: Li, Zhe, Lukasik, Steven M., Liu, Yizhou, Grembecka, Jolanta, Bielnicka, Izabela, Bushweller, John H., Speck, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783549/
https://ncbi.nlm.nih.gov/pubmed/17059830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.10.002
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