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Role for rearranged variable gene segments in directing secondary T cell receptor α recombination

During the recombination of variable (V) and joining (J) gene segments at the T cell receptor α locus, a VαJα joint resulting from primary rearrangement can be replaced by subsequent rounds of secondary rearrangement that use progressively more 5′ Vα segments and progressively more 3′ Jα segments. T...

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Detalhes bibliográficos
Main Authors: Hawwari, Abbas, Krangel, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783412/
https://ncbi.nlm.nih.gov/pubmed/17210914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608248104
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