Specific immunoglobulin E responses in ZAP-70-deficient patients are mediated by Syk-dependent T-cell receptor signalling

ZAP-70 deficiency is a rare primary immunodeficiency characterized by the absence of peripheral CD8(+) T cells and defects in T-cell receptor (TCR) signalling. T cells in ZAP-70-deficient patients are assumed to have no helper functions for B-cell immunoglobulin synthesis, whereas the patients rarel...

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Autors principals: Toyabe, Shin-ichi, Watanabe, Akihiro, Harada, Waka, Karasawa, Tamaki, Uchiyama, Makoto
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2001
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783225/
https://ncbi.nlm.nih.gov/pubmed/11412303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2001.01246.x
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