Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry

To study the roles of anisotropic cell morphology and directionality of mechanical force in apoptosis, the spreading of human umbilical vein endothelial cells (HUVECs) was constrained by growing on micropatterned (MP) strips of fibronectin (FN, 20 μg/cm(2)) with widths of 15, 30, and 60 μm on silico...

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Bibliographic Details
Main Authors: Wu, Chia-Ching, Li, Yi-Shuan, Haga, Jason H., Kaunas, Roland, Chiu, Jeng-Jiann, Su, Fong-Chin, Usami, Shunichi, Chien, Shu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783086/
https://ncbi.nlm.nih.gov/pubmed/17229844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609806104
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