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Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene

The human mast cell line (HMC)-1 cell line is growth-factor independent because of a constitutive activity of the receptor tyrosine kinase Kit. Such deregulated Kit activity has also been suggested causative in gastrointestinal stromal tumours (GISTs) and mastocytosis. HMC-1 is the only established...

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Bibliografski detalji
Glavni autori: Sundström, Magnus, Vliagoftis, Harissios, Karlberg, Peter, Butterfield, Joseph H, Nilsson, Kenneth, Metcalfe, Dean D, Nilsson, Gunnar
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782858/
https://ncbi.nlm.nih.gov/pubmed/12519307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2003.01559.x
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