Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo

Bacterial DNA and oligonucleotides (ODN) containing CpG-motifs strongly activate cells of the immune system. Accordingly CpG-DNA is a powerful adjuvant in vaccination protocols for B-cell as well as for cytotoxic T-cell responses. A decisive propensity of CpG-DNA is its capacity to induce preferenti...

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Библиографические подробности
Главные авторы: Dalpke, Alexander H, Zimmermann, Stefan, Albrecht, Inka, Heeg, Klaus
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2002
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782689/
https://ncbi.nlm.nih.gov/pubmed/11972638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01410.x
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