Dual biological functions of an interleukin-1 receptor antagonist–interleukin-10 fusion protein and its suppressive effects on joint inflammation

The aim of this study was to construct and purify a novel interleukin-1 receptor antagonist (IL-1ra)–interleukin-10 (IL-10) fusion protein and determine its biological function and anti-inflammatory effects. The isolated cDNAs of two inhibitory cytokines (IL-1ra, IL-10) were used to construct a cDNA...

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Autors principals: Chang, Deh-Ming, Shyue, Song-Kun, Liu, Shao-Hsiang, Chen, Yen-Teen, Yeh, Chiou-Yueh, Lai, Jenn-Huang, Lee, Herng-Sheng, Chen, Ann
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2004
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782518/
https://ncbi.nlm.nih.gov/pubmed/15270736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2004.01910.x
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