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No evidence for the use of DIR, D–D fusions, chromosome 15 open reading frames or V(H)replacement in the peripheral repertoire was found on application of an improved algorithm, JointML, to 6329 human immunoglobulin H rearrangements
Antibody diversity is created by imprecise joining of the variability (V), diversity (D) and joining (J) gene segments of the heavy and light chain loci. Analysis of rearrangements is complicated by somatic hypermutations and uncertainty concerning the sources of gene segments and the precise way in...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1782349/ https://ncbi.nlm.nih.gov/pubmed/17005006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2006.02431.x |
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