No evidence for the use of DIR, D–D fusions, chromosome 15 open reading frames or V(H)replacement in the peripheral repertoire was found on application of an improved algorithm, JointML, to 6329 human immunoglobulin H rearrangements

Antibody diversity is created by imprecise joining of the variability (V), diversity (D) and joining (J) gene segments of the heavy and light chain loci. Analysis of rearrangements is complicated by somatic hypermutations and uncertainty concerning the sources of gene segments and the precise way in...

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Bibliographic Details
Main Authors: Ohm-Laursen, Line, Nielsen, Morten, Larsen, Stine R, Barington, Torben
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2006
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782349/
https://ncbi.nlm.nih.gov/pubmed/17005006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2006.02431.x
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