Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction

AIMS: PTEN is a novel tumour suppressor which exhibits tyrosine phosphatase activity as well as homology to the cytoskeletal proteins tensin and auxilin. Mutations of PTEN have been described in several human cancers and associated with their invasiveness and metastatic properties. Although not mali...

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Publicado en:	Arthritis Res
Autores principales:	Pap, Thomas, Franz, Juliane K, Hummel, Klaus M, Jeisy, Elvira, Gay, Renate, Gay, Steffen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 1999
Materias:	Primary Research
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17804/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11219390/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/ar69
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