Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction

AIMS: PTEN is a novel tumour suppressor which exhibits tyrosine phosphatase activity as well as homology to the cytoskeletal proteins tensin and auxilin. Mutations of PTEN have been described in several human cancers and associated with their invasiveness and metastatic properties. Although not mali...

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Publié dans:	Arthritis Res
Auteurs principaux:	Pap, Thomas, Franz, Juliane K, Hummel, Klaus M, Jeisy, Elvira, Gay, Renate, Gay, Steffen
Format:	Artigo
Langue:	Inglês
Publié:	BMC 1999
Sujets:	Primary Research
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17804/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11219390/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/ar69
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