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Mechanism for Intein C-Terminal Cleavage: A Proposal from Quantum Mechanical Calculations
Inteins are autocatalytic protein cleavage and splicing elements. A cysteine to alanine mutation at the N-terminal of inteins inhibits splicing and isolates the C-terminal cleavage reaction. Experiments indicate an enhanced C-terminal cleavage reaction rate upon decreasing the solution pH for the cl...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Biophysical Society
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1779973/ https://ncbi.nlm.nih.gov/pubmed/17085503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.092049 |
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