T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn’s disease

Background and aims: Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn’s disease (CD). Recently, a novel transcription factor T-box expressed in T cells (T-bet) has been reported as the master regulator of Th1 development. This study was designed to...

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Detalhes bibliográficos
Main Authors: Matsuoka, K, Inoue, N, Sato, T, Okamoto, S, Hisamatsu, T, Kishi, Y, Sakuraba, A, Hitotsumatsu, O, Ogata, H, Koganei, K, Fukushima, T, Kanai, T, Watanabe, M, Ishii, H, Hibi, T
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2004 by Gut 2004
Assuntos:
Inflammatory Bowel Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774174/
https://ncbi.nlm.nih.gov/pubmed/15306590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.024190
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