Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

The cellular target of leptomycin B (LMB), a nuclear export inhibitor, has been identified as CRM1 (exportin 1), an evolutionarily conserved receptor for the nuclear export signal of proteins. However, the mechanism by which LMB inhibits CRM1 still remains unclear. CRM1 in a Schizosaccharomyces pomb...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Kudo, Nobuaki, Matsumori, Nobuaki, Taoka, Hiroshi, Fujiwara, Daisuke, Schreiner, Erwin P., Wolff, Barbara, Yoshida, Minoru, Horinouchi, Sueharu
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17741/
https://ncbi.nlm.nih.gov/pubmed/10430904
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker