Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

The cellular target of leptomycin B (LMB), a nuclear export inhibitor, has been identified as CRM1 (exportin 1), an evolutionarily conserved receptor for the nuclear export signal of proteins. However, the mechanism by which LMB inhibits CRM1 still remains unclear. CRM1 in a Schizosaccharomyces pomb...

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Библиографические подробности
Главные авторы: Kudo, Nobuaki, Matsumori, Nobuaki, Taoka, Hiroshi, Fujiwara, Daisuke, Schreiner, Erwin P., Wolff, Barbara, Yoshida, Minoru, Horinouchi, Sueharu
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 1999
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC17741/
https://ncbi.nlm.nih.gov/pubmed/10430904
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