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Leptomycin B Alters the Subcellular Distribution of CRM1 (Exportin 1)

CRM1 (chromosome maintenance region 1, Exportin 1) binds to nuclear export signals and is required for nucleocytoplasmic transport of a large variety of proteins and RNP complexes. Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear ex...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem Biophys Res Commun
Main Authors: Rahmani, Khatera, Dean, David A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551409/
https://ncbi.nlm.nih.gov/pubmed/28412356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.04.042
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