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Leptomycin B Alters the Subcellular Distribution of CRM1 (Exportin 1)
CRM1 (chromosome maintenance region 1, Exportin 1) binds to nuclear export signals and is required for nucleocytoplasmic transport of a large variety of proteins and RNP complexes. Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear ex...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551409/ https://ncbi.nlm.nih.gov/pubmed/28412356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.04.042 |
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