Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis

Introduction: Interleukin 10 knockout (IL-10−/−) mice spontaneously develop a Th1 T cell mediated colitis with many similarities to Crohn’s disease. Daily injections of IL-10 are unable to induce remission in mice with established disease. In contrast, we have shown previously that intravenous admin...

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Bibliographic Details
Main Authors: Lindsay, J O, Ciesielski, C J, Scheinin, T, Brennan, F M, Hodgson, H J
Format: Artigo
Language:Inglês
Published: Copyright 2003 by Gut 2003
Subjects:
Inflammatory Bowel Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773714/
https://ncbi.nlm.nih.gov/pubmed/12801955
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