Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis

BACKGROUND: Therapeutic gene transfer is currently being evaluated as a potential therapy for inflammatory bowel disease. This study investigates the safety and therapeutic benefit of a locally administered lentiviral vector encoding murine interleukin-10 in altering the onset and relapse of dextran...

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Main Authors: Matsumoto, Hiroshi, Haga, Kazunori, Ohno, Izumi, Hiraoka, Kei, Kimura, Takahiro, Hermann, Kip, Kasahara, Noriyuki, Anton, Peter, McGowan, Ian
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991919/
https://ncbi.nlm.nih.gov/pubmed/24712338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-14-68
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