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Rapidly progressive adenomatous polyposis in a patient with germline mutations in both the APC and MLH1 genes: the worst of two worlds

The two most common inherited forms of colorectal cancer are familial adenomatous polyposis and hereditary non-polyposis colorectal cancer. Simultaneous inheritance of both an APC gene mutation and a mismatch repair gene (for example, MLH1) mutation has never been described. In the present case repo...

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Detalhes bibliográficos
Main Authors: Scheenstra, R, Rijcken, F E M, Koornstra, J J, Hollema, H, Fodde, R, Menko, F H, Sijmons, R H, Bijleveld, C M A, Kleibeuker, J H
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773670/
https://ncbi.nlm.nih.gov/pubmed/12740349
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