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Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis
Introduction: Interleukin 10 knockout (IL-10−/−) mice spontaneously develop a Th1 T cell mediated colitis with many similarities to Crohn’s disease. Daily injections of IL-10 are unable to induce remission in mice with established disease. In contrast, we have shown previously that intravenous admin...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Copyright 2003 by Gut
2003
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1773574/ https://ncbi.nlm.nih.gov/pubmed/12584217 |
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