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A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability

Background: The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital to methylation reactions. A polymorphic variant (TT) has been linked to reduced levels of plasma folate, aberrant DNA methylation in leucocytes, and increased risk of col...

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Autori principali: Shannon, B, Gnanasampanthan, S, Beilby, J, Iacopetta, B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Copyright 2002 by Gut 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773174/
https://ncbi.nlm.nih.gov/pubmed/11889073
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