Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients

AIMS: To test prospectively the predictive value of germinal gene polymorphisms related to fluorouracil (FU) and oxaliplatin (Oxa) pharmacodynamics on toxicity and responsiveness of colorectal cancer (CRC) patients receiving FOLFOX therapy. METHODS: Advanced CRC patients (n= 117) receiving FOLFOX 7...

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Detalhes bibliográficos
Main Authors: Etienne-Grimaldi, Marie-Christine, Milano, Gérard, Maindrault-Gœbel, Frédérique, Chibaudel, Benoist, Formento, Jean-Louis, Francoual, Mireille, Lledo, Gérard, André, Thierry, Mabro, May, Mineur, Laurent, Flesch, Michel, Carola, Elisabeth, de Gramont, Aimery
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830598/
https://ncbi.nlm.nih.gov/pubmed/20078613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03556.x
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