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A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability
Background: The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital to methylation reactions. A polymorphic variant (TT) has been linked to reduced levels of plasma folate, aberrant DNA methylation in leucocytes, and increased risk of col...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Copyright 2002 by Gut
2002
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1773174/ https://ncbi.nlm.nih.gov/pubmed/11889073 |
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