Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis

Background: The trisubstituted methylxanthine derivative pentoxifylline inhibits hepatic stellate cell proliferation and collagen synthesis in vitro. The antifibrotic effect of pentoxifylline in a suitable in vivo model of chronic liver fibrogenesis remains to be tested. Methods: Groups of adult rat...

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Main Authors: Raetsch, C, Jia, J D, Boigk, G, Bauer, M, Hahn, E G, Riecken, E-O, Schuppan, D
格式: Artigo
語言:Inglês
出版: Copyright 2002 by Gut 2002
主題:
Biliary Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773098/
https://ncbi.nlm.nih.gov/pubmed/11788567
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