Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively

The assembly of the polyketide backbone of rifamycin B on the type I rifamycin polyketide synthase (PKS), encoded by the rifA–rifE genes, is terminated by the product of the rifF gene, an amide synthase that releases the completed undecaketide as its macrocyclic lactam. Inactivation of rifF gives a...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yu, Tin-Wein, Shen, Yuemao, Doi-Katayama, Yukiko, Tang, Li, Park, Cheonseok, Moore, Bradley S., Richard Hutchinson, C., Floss, Heinz G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 1999
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC17730/
https://ncbi.nlm.nih.gov/pubmed/10430893
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