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Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively

The assembly of the polyketide backbone of rifamycin B on the type I rifamycin polyketide synthase (PKS), encoded by the rifA–rifE genes, is terminated by the product of the rifF gene, an amide synthase that releases the completed undecaketide as its macrocyclic lactam. Inactivation of rifF gives a...

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Hlavní autoři: Yu, Tin-Wein, Shen, Yuemao, Doi-Katayama, Yukiko, Tang, Li, Park, Cheonseok, Moore, Bradley S., Richard Hutchinson, C., Floss, Heinz G.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC17730/
https://ncbi.nlm.nih.gov/pubmed/10430893
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