A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil

Deamination of cytosine to uracil is the most common promutagenic change in DNA, and it is greatly increased at the elevated growth temperatures of hyperthermophilic archaea. If not repaired to cytosine prior to replication, uracil in a template strand directs incorporation of adenine, generating a...

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Main Authors: Greagg, Martin A., Fogg, Mark J., Panayotou, George, Evans, Steven J., Connolly, Bernard A., Pearl, Laurence H.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17729/
https://ncbi.nlm.nih.gov/pubmed/10430892
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