5-Fluorouracil/irinotecan induced lethal toxicity as a result of a combined pharmacogenetic syndrome: report of a case

Combination cancer chemotherapy induced toxicity can be associated with combined pharmacogenetic syndromes. Dihydropyrimidine dehydrogenase (DPD) is the principal enzyme involved in the catabolic detoxification of 5-fluorouracil (5FU). A heterozygous G > A transition at the 5′ splicing donor cons...

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Detalhes bibliográficos
Main Authors: Steiner, M, Seule, M, Steiner, B, Bauer, I, Freund, M, Köhne, C H, Schuff-Werner, P
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2005 Journal of Clinical Pathology 2005
Assuntos:
Short Reports/Case Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1770668/
https://ncbi.nlm.nih.gov/pubmed/15858133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jcp.2004.022319
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