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Structural insights into RNA quality control: The Ro autoantigen binds misfolded RNAs via its central cavity

The Ro 60 kDa autoantigen is a major target of the immune response in patients with systemic lupus erythematosus. In vertebrate cells, Ro binds misfolded small RNAs and likely functions in RNA quality control. In eukaryotes and bacteria, Ro also associates with small RNAs called Y RNAs. We present s...

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Hlavní autoři: Stein, Adam J., Fuchs, Gabriele, Fu, Chunmei, Wolin, Sandra L., Reinisch, Karin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1769319/
https://ncbi.nlm.nih.gov/pubmed/15907467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2005.03.009
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