Site-directed mutagenesis of histidine residues in Clostridium perfringens alpha-toxin.
Mutagenesis of H-68 or -148 in Clostridium perfringens alpha-toxin resulted in complete loss of hemolytic, phospholipase C, sphingomyelinase, and lethal activities of the toxin. These activities of the variant toxin at H-126 or -136 decreased by approximately 100-fold of the activities of the wild-t...
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| 出版年: | J Bacteriol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology (ASM)
1995
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176721/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7868589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.177.5.1179-1185.1995 |
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