Site-directed mutagenesis of histidine residues in Clostridium perfringens alpha-toxin.

Mutagenesis of H-68 or -148 in Clostridium perfringens alpha-toxin resulted in complete loss of hemolytic, phospholipase C, sphingomyelinase, and lethal activities of the toxin. These activities of the variant toxin at H-126 or -136 decreased by approximately 100-fold of the activities of the wild-t...

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Bibliografiske detaljer

Udgivet i:	J Bacteriol
Principais autores:	Nagahama, M, Okagawa, Y, Nakayama, T, Nishioka, E, Sakurai, J
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176721/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7868589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.177.5.1179-1185.1995
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