Recombinant bacillus Calmette–Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model

Tuberculosis (TB) continues to ravage humanity, causing 2 million deaths per year. A vaccine against TB more potent than the current live vaccine, bacillus Calmette–Guérin (BCG), is desperately needed. Using two commercially available strains of BCG as host strains, BCG Connaught and Tice, we have c...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Horwitz, Marcus A., Harth, Günter, Dillon, Barbara Jane, Masleša-Galić, Saša
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2000
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11095745/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250480397
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