Recombinant bacillus Calmette–Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model

Tuberculosis (TB) continues to ravage humanity, causing 2 million deaths per year. A vaccine against TB more potent than the current live vaccine, bacillus Calmette–Guérin (BCG), is desperately needed. Using two commercially available strains of BCG as host strains, BCG Connaught and Tice, we have c...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Horwitz, Marcus A., Harth, Günter, Dillon, Barbara Jane, Masleša-Galić, Saša
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11095745/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250480397
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