Recombinant bacillus Calmette–Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model

Tuberculosis (TB) continues to ravage humanity, causing 2 million deaths per year. A vaccine against TB more potent than the current live vaccine, bacillus Calmette–Guérin (BCG), is desperately needed. Using two commercially available strains of BCG as host strains, BCG Connaught and Tice, we have c...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Horwitz, Marcus A., Harth, Günter, Dillon, Barbara Jane, Masleša-Galić, Saša
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2000
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11095745/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250480397
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