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The IL-15/IL-15Rα on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells

We previously described unique features of the IL-15 receptor (IL-15R)α. IL-15Rα by itself forms stable complexes with IL-15 on cell surfaces and presents IL-15 in trans to neighboring natural killer/T cells. Moreover, the membrane IL-15/IL-15Rα complexes (membIL-15) undergo endosomal internalizatio...

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Bibliografske podrobnosti
Main Authors: Sato, Noriko, Patel, Hiral J., Waldmann, Thomas A., Tagaya, Yutaka
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766429/
https://ncbi.nlm.nih.gov/pubmed/17202253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610115104
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